Table 1. Efficiency of predicting supertype binding by prototype allele algorithms.

		Percent of supertype binders predicted*
Source	Refs.	A2	A11	B7	A1	A24	DR1
HCV	15, 21†	88 (15 of 17)‡	71 (10 of 14)	0 (0 of 2)	50 (3 of 6)	40 (2 of 5)	100 (6 of 6)
P. falciparum§	15, 22, 23†	82 (9 of 11)	86 (6 of 7)	0 (0 of 1)	67 (2 of 3)	78 (7 of 9)	78 (7 of 9)
Mage2/3	15, 26†	57 (8 of 14)	100 (6 of 6)	100 (4 of 4)	80 (4 of 5)	0 (0 of 1)	100 (3 of 3)
HBV	15, 25†	63 (12 of 19)	50 (6 of 12)	75 (6 of 8)	78 (7 of 9)	65 (11 of 17)	92 (11 of 12)
Total		72 (44 of 61)	72 (28 of 39)	67 (10 of 15)	70 (16 of 23)	63 (20 of 32)	90 (27 of 30)

^*A supertype binder is a peptide with the capacity to bind ≥50% of the MHC molecules in a given supertype.

^†J.S. and A.S., unpublished observations.

^‡The numbers in parentheses indicate the number of supertype binders identified by the respective algorithm versus the total number of source-derived supertype binders.

^§Supertype peptides derived from the four previously well characterized P. falciparum antigens (PfCSP, PfSSP2, PfLSA, and PfEXP1).