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. 2003 Aug 6;100(17):9958–9961. doi: 10.1073/pnas.1733025100

Fig. 1.

Fig. 1.

Hair follicle stem cells in the hair-growth cycle. (Upper) Cartoon showing position of nestin-GFP stem cells at each stage of the hair follicle cycle. SG, sebaceous gland; EP, epidermis. (Lower a) Nestin-GFP-expressing hair follicle stem cells (red arrow) located in the hair follicle bulge area in telogen phase. (b) Day 2 after anagen induction by depilation. Note the new hair follicle cells (white arrow) formed directly from the bulge nestin-GFP-expressing stem cells. (c–e)Day4(c), day 6 (d), and day 10 (e) after anagen induction by depilation. Note the nestin-GFP-expressing outer-root sheath cells (white arrows) in the upper two-thirds of the hair follicle. (f and g) Day 19 (f) and day 20 (g) after depilation. Note in f and g that the hair follicles are in the catagen phase and are undergoing regression and degeneration, including the nestin-GFP-expressing cells in the outer-root sheath. The bulge area nestin-GFP-expressing stem cells remain. (h) Hair follicle cycling in telogen phase.