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. 2003 Aug 8;100(17):9974–9979. doi: 10.1073/pnas.1732638100

Table 1. MYC overexpression induces chromosomal breaks, deletions, and translocations.

Karyotypic abnormality, %
Cell line Treatment, h Chromatid breaks Deletions Translocations
NHF-BABE
    Synchronized None 0 0 0
    Synchronized E2, 48 1 0 0
    Asynchronized None 0 0 0
    Asynchronized E2, 48 1 0 0
NHF-MYCER
    Synchronized None 0 1 0
    Synchronized E2, 48 12 3 3
    Asynchronized None 0 1 0
    Asynchronized E2, 48 2 1 0.8

At least 100 metaphases were analyzed per treatment.