Table 1. MYC overexpression induces chromosomal breaks, deletions, and translocations.
|
Karyotypic abnormality, %
|
||||
|---|---|---|---|---|
| Cell line | Treatment, h | Chromatid breaks | Deletions | Translocations |
| NHF-BABE | ||||
| Synchronized | None | 0 | 0 | 0 |
| Synchronized | E2, 48 | 1 | 0 | 0 |
| Asynchronized | None | 0 | 0 | 0 |
| Asynchronized | E2, 48 | 1 | 0 | 0 |
| NHF-MYCER | ||||
| Synchronized | None | 0 | 1 | 0 |
| Synchronized | E2, 48 | 12 | 3 | 3 |
| Asynchronized | None | 0 | 1 | 0 |
| Asynchronized | E2, 48 | 2 | 1 | 0.8 |
At least 100 metaphases were analyzed per treatment.