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. 2003 Aug 6;100(17):9986–9990. doi: 10.1073/pnas.1733772100

Fig. 1.

Fig. 1.

Comparison of cardiac hypertrophy after aortic banding in WT and AC5–/–. Transverse aortic banding or sham operation was applied to either WT or AC5–/–. (A) LVW (mg)/TL (mm) was determined at 1 and 3 wk. LVW/TL of sham-operated animals was obtained at 1 and 3 wk, and the data were combined. The degree of cardiac hypertrophy increased progressively at 1 and 3 wk but was similar in both WT and AC5–/– (n = 6for1wkand n = 8–10 for 3 wk). (B) Cardiac myocyte cross-sectional area was determined at 3 wk. There was also no significant difference in myocyte cross-sectional area between WT and AC5–/–. The fact that increases in LVW/TL were greater than increases in myocyte cross-sectional area with aortic banding can be ascribed to the fact that cross-sectional area assesses only two of three dimensions of myocyte size (increases in thickness are not measured) (n = 4–5 each for sham and banded). NS, not significant.