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. 1993 May;37(5):1150–1153. doi: 10.1128/aac.37.5.1150

Comparative susceptibilities of 173 aerobic and anaerobic bite wound isolates to sparfloxacin, temafloxacin, clarithromycin, and older agents.

E J Goldstein 1, D M Citron 1
PMCID: PMC187919  PMID: 8390810

Abstract

The in vitro activities of sparfloxacin, temafloxacin, ciprofloxacin, ofloxacin, clarithromycin, erythromycin, tetracycline, cephalothin, penicillin G, and amoxicillin-clavulanic acid against 173 recent clinical bite wound isolates were determined by agar dilution. Sparfloxacin was active against all strains (MIC for 90% of strains tested, < or = 1 micrograms/ml) except for most fusobacteria and one-third of the Prevotella spp. The other fluoroquinolones had similar activities but higher MICs, especially for streptococci. Clarithromycin was more active against many isolates including Pasteurella multocida than erythromycin, with MICs of < or = 2 micrograms/ml (versus 4 micrograms/ml for erythromycin).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barry A. L., Fuchs P. C. In vitro activities of sparfloxacin, tosufloxacin, ciprofloxacin, and fleroxacin. Antimicrob Agents Chemother. 1991 May;35(5):955–960. doi: 10.1128/aac.35.5.955. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brook I. Microbiology of human and animal bite wounds in children. Pediatr Infect Dis J. 1987 Jan;6(1):29–32. doi: 10.1097/00006454-198701000-00008. [DOI] [PubMed] [Google Scholar]
  3. Chin N. X., Gu J. W., Yu K. W., Zhang Y. X., Neu H. C. In vitro activity of sparfloxacin. Antimicrob Agents Chemother. 1991 Mar;35(3):567–571. doi: 10.1128/aac.35.3.567. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Finegold S. M., Molitoris E., Reeves D., Wexler H. M. In-vitro activity of temafloxacin against anaerobic bacteria: a comparative study. J Antimicrob Chemother. 1991 Dec;28 (Suppl 100):25–30. doi: 10.1093/jac/28.suppl_c.25. [DOI] [PubMed] [Google Scholar]
  5. Goldstein E. J., Citron D. M. Comparative activities of cefuroxime, amoxicillin-clavulanic acid, ciprofloxacin, enoxacin, and ofloxacin against aerobic and anaerobic bacteria isolated from bite wounds. Antimicrob Agents Chemother. 1988 Aug;32(8):1143–1148. doi: 10.1128/aac.32.8.1143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Goldstein E. J., Citron D. M. Comparative activity of ciprofloxacin, ofloxacin, sparfloxacin, temafloxacin, CI-960, CI-990, and WIN 57273 against anaerobic bacteria. Antimicrob Agents Chemother. 1992 May;36(5):1158–1162. doi: 10.1128/aac.36.5.1158. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Goldstein E. J., Citron D. M., Richwald G. A. Lack of in vitro efficacy of oral forms of certain cephalosporins, erythromycin, and oxacillin against Pasteurella multocida. Antimicrob Agents Chemother. 1988 Feb;32(2):213–215. doi: 10.1128/aac.32.2.213. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Goldstein E. J., Citron D. M., Vagvolgyi A. E., Finegold S. M. Susceptibility of bite wound bacteria to seven oral antimicrobial agents, including RU-985, a new erythromycin: considerations in choosing empiric therapy. Antimicrob Agents Chemother. 1986 Apr;29(4):556–559. doi: 10.1128/aac.29.4.556. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hardy D. J., Hensey D. M., Beyer J. M., Vojtko C., McDonald E. J., Fernandes P. B. Comparative in vitro activities of new 14-, 15-, and 16-membered macrolides. Antimicrob Agents Chemother. 1988 Nov;32(11):1710–1719. doi: 10.1128/aac.32.11.1710. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Neu H. C. The development of macrolides: clarithromycin in perspective. J Antimicrob Chemother. 1991 Feb;27 (Suppl A):1–9. doi: 10.1093/jac/27.suppl_a.1. [DOI] [PubMed] [Google Scholar]
  11. Sands M., Ashley R., Brown R. Trimethoprim/sulfamethoxazole therapy of Pasteurella multocida infection. J Infect Dis. 1989 Aug;160(2):353–354. doi: 10.1093/infdis/160.2.353. [DOI] [PubMed] [Google Scholar]
  12. Shure D. Radiographically occult endobronchial obstruction in bronchogenic carcinoma. Am J Med. 1991 Jul;91(1):19–22. doi: 10.1016/0002-9343(91)90068-9. [DOI] [PubMed] [Google Scholar]
  13. Stevens D. L., Higbee J. W., Oberhofer T. R., Everett E. D. Antibiotic susceptibilities of human isolates of Pasteurella multocida. Antimicrob Agents Chemother. 1979 Sep;16(3):322–324. doi: 10.1128/aac.16.3.322. [DOI] [PMC free article] [PubMed] [Google Scholar]

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