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. 2000 Oct 24;97(23):12498–12502. doi: 10.1073/pnas.220425497

Figure 1.

Figure 1

RNA sequence elements identified as in vitro cleavage substrates for PMR-1. (Upper) The solved secondary structure of a region in the 5′ end of albumin mRNA bearing mapped PMR-1 cleavage sites (16). APyrUGA consensus cleavage sites are boxed. (Lower) The sequence of the vitellogenin B1 3′-UTR bound by vigilin containing the only two APyrUGA elements present in the 3′-UTR of vitellogenin mRNA (18). The sites for cleavage of albumin mRNA within the APyrUGA elements are indicated (Upper) with open arrows, and the PMR-1 cleavage sites in the vitellogenin mRNA 3′-UTR determined in Fig. 2 are indicated with filled arrows, with the relative strength of each site represented by the size of each arrow.