(Left) Western analysis of p53 pathway. HeLa cell
proteins were harvested at the indicated hours after E2 infection or
mock-infection, electrophoresed, transferred, and probed with
antibodies specific for p53, p21, or human mdm2, as indicated.
(Right) Northern analysis of p53 pathway. HeLa cell RNA
was isolated at the indicated hours after E2 infection or
mock-infection. After electrophoresis and transfer, p53, p21, and mdm2
mRNA was detected by hybridization to the appropriate radiolabeled cDNA
probe.