Figure 7.

Effect of HPV16 E6/E7 expression on the acute response to the E2 protein. Cell lines derived from individual clones of cells infected with control retrovirus (LXSN) or HPV16 E6/E7 retrovirus were analyzed. (Top) DNA synthesis by the indicated cell lines was measured by incorporation of tritiated thymidine 48 h after infection with the E2 virus, expressed as the percentage of DNA synthesis by each clone after mock-infection. (Middle) Expression of p105^Rb in the indicated cell lines after mock-infection or 1 day after infection with the E2 virus. (Bottom) Expression of cyclin A in the indicated cell lines after mock-infection or 1 or 2 days after infection with the E2 virus.