Effects of hsp90 deletions on p23 binding. (A)
GST-1–728 and GST-1–698 were compared for p23 binding in the presence
or absence of 2 mM ATP. Background measurements were assessed by
omitting p23 or the p23 antibody JJ3. (B) hsp90,
GST-1–728, and GST-1–573 were assessed for p23 binding in the
presence or absence of ATP, adenosine 5′-diphosphate, or geldanamycin
(GA). (C) The GST-hsp90 constructs indicated were
compared for p23 binding in the presence or absence of ATP. In all
cases, the hsp90 constructs from p23 complexes were resolved by
SDS/PAGE and stained with Coomassie Blue.