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. 2000 Nov 7;97(23):12541–12546. doi: 10.1073/pnas.97.23.12541

Figure 1.

Figure 1

Schematic illustration of the cDNA structures of human ADAR1 deaminase, PKR kinase, and chimeric PKR-ADAR1 proteins. Zα and Zβ, two Z-DNA-binding domains of ADAR1; RI, RII, and RIII, three copies of the dsRBM of ADAR1; R1 and R2, two copies of the dsRBM of PKR; and C, catalytic domain. The methionine at position 296 used to express the M296 constitutive form of ADAR1 (8, 37) is indicated; a, b, and c refer to the three splice variants of ADAR1 (24). The deletion mutants of ADAR1 (DL1-DL3) and chimeric PKR-ADAR1 constructs (CH1-CH5), including the three CH4 (a, b, c) and two CH5 (a, b) splice variants, are shown. Numbers immediately above or below the schematics refer to the amino acid residue positions, including the positions of the ADAR deletions (DL) and the junctions of the PKR-ADAR1 chimeric (CH) proteins. K60E and K150E, point mutations of the dsRBM motifs from PKR present in CH4-b and CH5-b.