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. Author manuscript; available in PMC: 2008 May 4.
Published in final edited form as: Biochem Biophys Res Commun. 2007 Mar 7;356(2):481–486. doi: 10.1016/j.bbrc.2007.03.003

Figure 4.

Figure 4

A model of how bacterial pathogens may use the TIR-like proteins to inhibit NFκB signaling in infected cells. Top panel: a simplified depiction of the Toll-like receptor signaling pathway with a productive receptor-adaptor TIR-TIR interaction. Bottom panel: the presence of bacterial TLPs, prevents the inflammatory signal to proceed by the formation of a bacterial-host TIR-TIR interaction. Legend: PAMP, pathogen-associated molecular patterns; TIR, Toll/IL-1 receptor/plant Resistance domain; DD, death domain; CC, coiled-coil.