Figure 4.
The relationship between AZT-DNA incorporation and induced HPRT mutant frequency values obtained following exposure to AZT alone or after subtracting the expected contribution in mutagenic response from ddI alone in the cases where AZT-ddI treatments were combined. The levels of AZT-DNA incorporation were found to have a linear correlation with induced HPRT mutant frequency values following exposure of TK6 cells to 33 μM AZT, 100 μM AZT, 33 μM AZT + 33 μM ddI, and 100 μM AZT + 100 μM ddI.
