Table 2.
Clones isolated with RaSH with the restriction enzyme EcoRII
| Nomenclature* | Identity† | Mda type‡ |
|---|---|---|
| mda-E-28, E-34, E-38, E-41, E-45, E-49, E-50 | Fibronectin | Type IV |
| mda-E-31 | 2′-5′ oligoadenylate synthetase | Type I |
| mda-E-32, E-57, E-58 | LIF | Type II |
| mda-E-35 | Transporter 1, ABC | Type I |
| mda-E-36, E-42, E-52 | HLA-B | Type I |
| mda-E-39 | KIAA0180 | Type II |
| mda-E-40 | Vimentin | Type I |
| mda-E-44 | Tumor necrosis factor-α | Type II |
| mda-E-46, E-55 | Calcium-activated potassium channel | Type IV |
| mda-E-47 | Ninjurin 1 | Type IV |
| mda-E-51 | HMG-Y protein isoform | Type I |
| mda-E-54 | Proteasome 26S subunit | Type IV |
| mda-E-61 | Human GADD34 | Type II |
| mda-E-68 | mda-6 (p21, Waf1, CIP1, SDI1) | Type IV |
| mda-E-43, E-63, E-64 | Novel | Type I |
*
Clones are designated as melanoma differentiation-associated (mda) and the E designation refers to the fact that the restriction enzyme EcoRII was used for isolation by the RaSH approach.
†
Sequences were searched against various DNA databases to determine sequence identities. Novel, no similar sequence reported in current DNA databases.
‡
Type I mda gene, inducible by IFN-β and IFN-β + MEZ; Type II mda gene, inducible by MEZ and IFN-β + MEZ; Type III mda gene, inducible by IFN-β, MEZ and IFN-β + MEZ; Type IV mda gene, inducible predominantly by IFN-β + MEZ.