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Blockade of CTLA-4 increases the frequency of Th1 but not Th2 responders in coimmunized animals. Blockade of CTLA-4 in animals primed with a 5:1 mixture of PLP-Q/PLP-139–151 results in an increase in IFN-γ secretors responding to PLP-139–151 (A) and PLP-Q (C). The frequency of IL-4 responders to PLP-139–151 (B) and PLP-Q (D) is not affected. Experiments were performed as in Fig. 2. These data are representative of four separate experiments.
