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. 2000 Oct 24;97(23):12711–12716. doi: 10.1073/pnas.220423597

Figure 4.

Figure 4

Blockade of CTLA-4 does not increase the frequency of cross-reactive cells. Anti-CTLA-4 does not result in cross-reactive IFN-γ responders to PLP-Q from PLP-139–151-primed animals (A) or to PLP-139–151 from PLP-Q-primed animals (C). CTLA-4 blockade can result in a decrease in the number of cross-reactive IL-4 responders. (B) Few IL-4 secretors were observed from PLP-139–151-primed animals in response to PLP-Q. Cross-reactive IL-4 secretors were observed from PLP-Q-primed animals in response to PLP-139–151. (D) CTLA-4 blockade resulted in a decreased number of IL-4-secreting cells at the highest concentrations of PLP-139–151 used for detection. Experiments were performed as described in the legend of Fig. 2. These data are representative of three experiments for A, B, and C and two of three experiments for D.