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. 2000 Oct 24;97(23):12711–12716. doi: 10.1073/pnas.220423597

Figure 5.

Figure 5

The frequency of cross-reactive IL-2 secretors decreases if CTLA-4 is blocked during priming. (A) Few responders are seen from PLP-139–151-primed animals in response to PLP-Q. (B) PLP-Q immunization primes cells that secrete IL-2 in response to PLP-139–151 and the frequency of these responders is reduced if CTLA-4 was blocked during priming. These experiments were performed as in Fig. 2, but with antibodies to mouse IL-2. The data are representative of two and three separate experiments for A and B, respectively.