Skip to main content
. 2000 Oct 31;97(23):12741–12745. doi: 10.1073/pnas.220176997

Figure 1.

Figure 1

Plasma ALT levels in control and GstP null mice after treatment with acetaminophen. (A) Male GstP1/P2(−/−) and GstP1/P2(+/+) mice (n = 5) were treated with a single dose of acetaminophen (250 mg/kg body weight) by gavage, and plasma ALT values were determined as detailed in Materials and Methods. ■, GstP1/P2(+/+); ○, GstP1/P2(−/−). **, P < 0.01; * P < 0.05. (B) Male GstP1/P2(−/−) and GstP1/P2(+/+) mice (n = 5–10) were treated with a single i.p. dose of acetaminophen ranging from 100 to 350 mg/kg body weight, and plasma ALT values were determined as detailed in Materials and Methods. ■, GstP1/P2(+/+); ○, GstP1/P2(−/−). *, statistical difference between controls and nulls (***, P < 0.001).