Table 1.
HOX expression in lung cancers by degenerate PCR
| HOX | DNA control | Normal lung | GLC20 | H187 | H460 | H661 | H1648 | H322 | H226 | H290 | H513 | H28 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A1 | 11 | 5 | 14 | 24 | 25 | |||||||
| B1 | 12 | |||||||||||
| C1 | 3 | 2 | 5 | 4 | 11 | |||||||
| A2 | 2 | 3 | ||||||||||
| A3 | 3 | 13 | 4 | 16 | 2 | 34 | 2 | 33 | 2 | 2 | 8 | |
| B3 | 1 | 26 | 2 | 4 | 3 | 4 | 3 | 13 | 7 | 6 | ||
| A4 | 7 | 5 | 4 | 2 | 2 | 14 | 2 | 2 | 3 | 2 | ||
| B4 | 1 | 2 | 2 | |||||||||
| C4 | 2 | 24 | 10 | 3 | 2 | 6 | 13 | 9 | 6 | |||
| D4 | 1 | 2 | ||||||||||
| A5 | 3 | 8 | 2 | 6 | 8 | 2 | 4 | |||||
| B5 | 1 | |||||||||||
| A6 | 1 | 3 | ||||||||||
| B6 | 5 | 16 | 4 | 5 | 11 | 2 | ||||||
| C6/C8 | 2 | 2 | 4 | 20 | 10 | 33 | 3 | 7 | 13 | 2 | 6 | |
| A7 | 5 | 8 | 31 | 2 | 2 | 11 | ||||||
| B7 | 2 | 5 | 2 | 5 | 5 | 8 | ||||||
| B8 | 1 | 2 | 4 | 2 | 5 | 3 | ||||||
| D8 | 3 | 2 | 4 | 6 | 7 | 3 | ||||||
| A9 | 8 | 6 | 10 | 2 | 11 | 2 | 25 | |||||
| B9 | 5 | 19 | 20 | 18 | 17 | 10 | 3 | 2 | 53 | |||
| C9 | 6 | 2 | 14 | 4 | 5 | 7 | 5 | 3 | 10 | 2 | 3 | |
| D9 | 1 | 2 | 2 | 3 | ||||||||
| A10 | 5 | 13 | 2 | 5 | 29 | 3 | 25 | 25 | ||||
| D10 | 0 | 3 | 2 | |||||||||
| C12 | 2 | 4 | ||||||||||
| D12 | 0 | 2 | ||||||||||
| CDX1 | 1 | |||||||||||
| CDX2 | 0 | 2 | 8 | |||||||||
| GBX2 | 4 | 6 | 3 | 2 | 3 | 3 | ||||||
| Huh15 | 1 | 6 | 2 | 2 | 2 | 5 | ||||||
| Huh17 | 2 | |||||||||||
| Nkx-3.1 | 1 | 6 | ||||||||||
| Xlhbox8b | 1 | 2 |
The percentage of subclones corresponding to each identified HOX locus is listed. The sequence data did not discriminate between HOXC6 and C8, which are listed as C6/C8. The number of clones analyzed from each sample is as follows: DNA control (153), normal lung (62), CLC20-SCLC (48), H187-SCLC (51), H460-large cell (49), H661-large cell (42), H1648-adenocarcinoma (59), H322-bronchioalveolar (55), H226-squamous (36), H290-mesothelioma (61), H513-mesothelioma (44), H28-mesothelioma (36).