Figure 2.

Functional p53 and p21^CIP/WAF are essential for TNP-470-induced cell cycle arrest. The effects of TNP-470 on cell proliferation were evaluated by [³H]thymidine incorporation as described in Materials and Methods. (A) Dose-response curves of MPE cells from wild-type (wt), p21^{CIP/WAF−/−}, and p53^−/− mice. EC, endothelial cell. (B) Dose-response curves of HUVE cells and E6-HUVE cells. Results are presented as the percentage of drug-treated over control (vehicle only) and are shown as the mean and standard deviation of more than three determinants.