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. Author manuscript; available in PMC: 2008 Apr 1.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1884–1891. doi: 10.1167/iovs.06-0990

Figure 3.

Figure 3

Staurosporine induced proteolytic activities of tPA and uPA in a dose-dependent fashion. RGC-5 cells (4 × 103 cells/mL) were left untreated or were treated for 48 hours with 0.5 μM, 1.0 μM, and 2.0 μM staurosporine (in serum-free medium). (A) RGC-5 cells treated with staurosporine (up to 1.0 μM) differentiated and had increased neurite outgrowth. However, at a concentration of 2.0 μM, neurite outgrowth was significantly reduced (B). Scale bar, 40 μm. *P < 0.05, compared with untreated cells. #P < 0.05, compared with 0.5 μM staurosporine-treated cells. (C) RGC-5 cells left untreated expressed low levels of uPA but not tPA, whereas cells treated with staurosporine expressed increased levels of both tPA and uPA.