Table 2.

Population pharmacokinetic estimates.

	Clearance (l h−1)			KA (h−1)
	Male	Female	Volume (l)	Male	Female
NONMEM estimate	0.377	0.347	14.9	0.338	0.336
95% CI*	0.304–0.449	0.274–0.419		0.334–0.342	0.332–0.340
Individual estimates† (min, max)	0.085–0.777		7.8–25.2	0.06–1.37
WinBUGS estimate	0.375	0.347	17.5	0.511	0.509
Credible interval‡	0.218–0.680	0.184–0.694	12.1–37.8	0.29–0.81	0.29–0.82
Individual estimates† (min, max)		0.09–1.01	4.17–36.9	0.08–3.19

^*Confidence interval: conventional confidence intervals define a range for the expectation of an estimate in frequently repeated experiments.

^†Individual estimates: range of individual parameter Bayesian posterior estimates from the final model.

^‡Credible interval: statement in the Bayesian framework concerning the probability of an unknown population parameter falling in the specified interval in this experiment.