Table 2.

Pharmacokinetic data of diclofenac in the 20 male study participants classified by CYP2C9 genotype.

			Diclofenac			4′-OH Diclofenac
CYP2C9 genotype	Code	Clearance/F(L h−1)	tlag(h)	Cmax(µg L−1)	t1/2(h)	AUC last(µg h L−1)	tmax(h)	Cmax(µg L−1)
*1/*1	1	17.1	1.08	3124	0.89	321	2.33	96
	16	19.2	0.55	1797	1.8	–	–	–
	25	24.4	1.62	1473	0.77	423	3.1	122
	Mean	20.2	1.08	2131	1.2	372	2.7	109
*1/*2	2	23.6	1.00	2331	0.42	126	2.50	94
	22	32.5	0.53	910	1.3	402	2.03	100
	23	24.2	0.58	1719	1.2	34	2.53	29
	24	34.8	1.2	1034	1.2	266	3.17	89
	Mean	28.8	0.83	1498	1.0	207	2.56	78
*1/*3	7	31.3	3.18	1151	0.65	102	5.17	80
	11	16.7	0.58	2462	1.4	502	2.08	102
	12	22.7	1.03	1498	0.98	86	2.57	39
	20	18.8	0.02	2604	1.2	210	1.53	142
	Mean	22.4	1.20	1929	1.1	225	2.84	91
*2/*2	3	26.7	1.07	1554	1.1	380	2.10	101
	18	21.3	1.52	2963	1.1	342	2.52	116
	33	41.5	0.58	1405	0.27	221	2.08	205
	Mean	29.8	1.06	1974	0.81	314	2.23	141
*2/*3	4	71.5	1.55	278	1.5	281	6.05	98
	9	32.6	4.07	734	0.85	813	5.03	540
	19	18.5	1.02	2229	0.91	267	2.02	125
	Mean	40.9	2.21	1081	1.1	453	4.37	254
*3/*3	5	25.7	1.05	1418	0.97	306	2.57	119
	5	25.7	1.05	1418	0.97	306	2.57	119
	13	17.1	0.6	1650	1.1	841	2.10	99
	14	26.5	1.57	1764	1.3	181	2.58	58
	Mean	23.1	1.07	1610	1.1	442	2.42	92
All	Mean (95%CI)	27.3 (21.5–33.1)	1.2 (0.8–1.7)	1704 (1360–2050	1.0 (0.88–1.2)	321 (217–425)	2.8 (2.3–3.4)	124 (72–176)

**4′-OH diclofenac could not be analysed in this subject.