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Definitions of inhibitory quotient (IQ) and virtual inhibitory quotient (vIQ) bringing together the drug concentration and a pharmacodynamic measure in a simple equation IQ = Ctrough/IC50, where Ctrough is the drug concentration at the end of the dosing interval and IC50 is the concentration of drug producing 50% inhbition of virus in vitro. vIQ = Ctrough/IC50 of WT virus x Virtual Phenotype (VP), where the VP is determined from the genotype and matched phenotype in a data base.
