. 2003 Mar;55(3):252–263. doi: 10.1046/j.1365-2125.2003.01765.x

Table 5.

Statistically significant relationships between covariates and pharmacokinetic parameters in the final model.

Statistically significant effect	Change in independent variable	Effect on the PK parameter	Effect on systemic exposure
ALP on CL of 5-FU	ALP × 2	CL of 5-FU 11% lower	AUC 12% higher
	ALP × 5	CL of 5-FU 24% lower	AUC 31% higher
CLCR on CL of FBAL	CLCR × 0.5	CL of FBAL 35% lower	AUC 53% higher
CLCR on V of FBAL	CLCR × 0.5	V of FBAL 24% lower	C_max 41% higher
BSA on V of FBAL	BSA × 1.3	V of FBAL 24% higher	C_max 19% lower