Table 7.
P-values (−2 log likelihood statistic) from logistic regression analysis for systemic exposure and safety outcomes (n = 481).
| Exposure measure | All adverse events (no. of events: 184) | Diarrhoea (no. of events: 59) | Hand–foot syndrome (no. of events: 87) | Hyperbilirubinaemia (no. of events: 115) |
|---|---|---|---|---|
| 5′-DFUR AUC | 0.121 | 0.401 | 0.065 | 0.662 |
| 5′-DFUR Cmax | 0.199 | 0.776 | 0.069 | 0.127 |
| 5-FU AUC | 0.503 | 0.737 | 0.090 | 0.025 |
| 5-FU Cmax | 0.864 | 0.957 | 0.599 | 0.832 |
| FBAL AUC | 0.144 | 0.035 | 0.384 | 0.468 |
| FBAL Cmax | 0.543 | 0.365 | 0.355 | 0.014 |