Table 8.

Cox regression analysis for systemic exposure and time to disease progression.

Exposure measure	Hazard ratio	95% CI (Wald)	P-value (Wald)
5′-DFUR AUC	0.996	0.97–1.02	0.75
5′-DFUR Cmax	0.965	0.93–1.00	0.068
5-FU AUC	1.626	1.15–2.29	0.0056
5-FU Cmax	1.097	0.72–1.67	0.66
FBAL AUC	0.989	0.97–1.01	0.16
FBAL Cmax	0.918	0.84–1.01	0.063

n = 481, 426 events.