Table 1.
Genotype and allele frequencies of CYP1A2 among Egyptians (present study) and Japanese subjects [7].
| Egyptian (present study) | Japanese [7] | |||
|---|---|---|---|---|
| Polymorphism | Number (n = 212) | Observed frequency | Expected* frequency | Observed frequency (n = 159) |
| CYP1A2*1C | ||||
| G/G | 185 | 87.20 | 86.50 | 61.60 |
| G/A | 25 | 11.80 | 13.00 | 34.60 |
| A/A | 2 | 1.00 | 0.50 | 3.80 |
| G allele vs A variant | 0.93: 0.07 (95% CI, 0.04–0.09) | 0.79: 0.21 (P < 0.0001) | ||
| CYP1A2*1D | ||||
| T/T | 81 | 38.30 | 36.00 | 33.80 |
| T/del | 92 | 43.30 | 48.00 | 48.40 |
| del/del | 39 | 18.40 | 16.00 | 17.80 |
| T allele vs del allele | 0.60: 0.40 (95% CI, 0.35–0.44) | 0.58: 0.42 (N.S.) | ||
| CYP1A2*1E | ||||
| T/T | 199 | 93.80 | 94.10 | 86.20 |
| T/G | 12 | 5.70 | 5.80 | 11.30 |
| G/G | 1 | 0.50 | 0.10 | 2.50 |
| T allele vs A variant | 0.97: 0.03 (95% CI, 0.02–0.05) | 0.92: 0.08 (P = 0.005) | ||
| CYP1A2*1F | ||||
| C/C | 23 | 10.80 | 10.30 | 16.40 |
| C/A | 89 | 42.00 | 43.50 | 44.60 |
| A/A | 100 | 47.20 | 46.20 | 39.00 |
| C allele vs A variant | 0.32: 0.68 (95% CI, 0.64–0.72) | 0.39: 0.61 (N.S.) | ||
n, Total number of subjects.
*
According to the Hardy–Weinberg law. The 95% confidence interval (95% CI) for all variants in our study is given. Differences in allele frequencies between Egyptians and Japanese were measured by Fisher's exact test. N.S., No significant differences (P > 0.05).