Table 3.

Cardiovascular effect of intravenous olprinone and aminophylline in asthmatic patients.

Time (min)
	Baseline	30	60	90	120	150	p	anova§
Systolic blood pressure (mmHg)
Aminophylline	130.9 ± 7.1	132.6 ± 5.4	127.1 ± 5.7	125.9 ± 6.3	130.4 ± 6.9	125.9 ± 5.1
Olprinone	122.4 ± 5.2	115.5 ± 5.7	113.6 ± 4.1	109.4 ± 3.7	108.5 ± 4.4	116.9 ± 4.8	0.2449
Combination	129.5 ± 5.0	125.0 ± 4.0	113.8 ± 4.2	114.9 ± 3.1	110.5 ± 4.5	113.6 ± 4.0
Saline	124.1 ± 2.6	123.3 ± 4.7	119.1 ± 5.9	118.4 ± 3.6	118.5 ± 4.5	121.5 ± 3.3
Diastolic blood pressure (mmHg)
Aminophylline	89.5 ± 4.6	85.2 ± 4.6	85.6 ± 4.9	85.2 ± 5.1	86.5 ± 5.1	83.6 ± 2.9
Olprinone	82.6 ± 4.1	73.3 ± 3.2*	85.6 ± 4.9††	67.2 ± 2.9*††	63.7 ± 2.6**††	63.4 ± 2.9**††	0.0174
Combination	84.5 ± 3.0	78.7 ± 3.0	73.6 ± 2.7†	70.2 ± 2.7*††	64.4 ± 3.9*††	65.5 ± 2.7**††
Saline	78.5 ± 4.2	82.7 ± 5.0	77.8 ± 4.7	80.5 ± 3.1	78.6 ± 3.6	80.1 ± 3.9
Heart rate (/min)
Aminophylline	81.4 ± 2.9	74.7 ± 2.4	75.5 ± 2.0	73.3 ± 2.6	71.5 ± 2.4	75.7 ± 3.0
Olprinone	83.7 ± 3.4	87.9 ± 3.9†	89.4 ± 4.6*†	92.9 ± 4.2**††	89.2 ± 4.5*††	95.4 ± 4.8**††	0.0032
Combination	79.6 ± 3.0	81.5 ± 2.9	95.2 ± 3.6**††	94.2 ± 3.8**††	94.5 ± 4.6**††	99.0 ± 5.4**††
Saline	79.7 ± 4.5	81.6 ± 5.3	76.2 ± 4.1	76.0 ± 3.9	74.7 ± 3.2	76.0 ± 37

All measurements were expressed as mean ± standard error of the mean (SEM).

^§Repeated-measure anova was used for differences between four time courses.

^*P < 0.05

^**P < 0.01 compared with saline.

^†p < 0.05

^††p < 0.01 compared with aminophylline.