Table 2.
Pain intensity, sum pain intensity (SUMPI) and mean differences between treatments reported after paracetamol 1000 mg × 4 or ibuprofen 600 mg × 4 on the day of surgery. Trial medication started 3 h after end of surgery. Pain scored on a 100-mm VAS. Data presented as mean (SD) and mean differences (95% CI).
| Mean pain intensity | ||||
|---|---|---|---|---|
| Time after surgery (h) | Paracetamol | Ibuprofen | Mean difference | n |
| 0 | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.00, 0.00) | 36 |
| 1 | 1.6 (6.1) | 2.6 (6.6) | 1.0 (−4.0, 2.1) | 36 |
| 2 | 10.8 (21.9) | 12.4 (20.2) | −1.7 (−11.2, 7.8) | 36 |
| 3 | 36.1 (32.0) | 40.9 (34.9) | −4.8 (−15.4, 5.8) | 36 |
| 3.5 | 21.1 (19.6) | 25.7 (27.1) | −4.6 (−12.4, 3.3) | 36 |
| 4 | 16.3 (17.5) | 18.4 (25.4) | −2.1 (−10.4, 6.1) | 36 |
| 5 | 19.0 (19.9) | 15.8 (22.5) | 3.2 (−5.1, 11.5) | 36 |
| 6 | 20.1 (20.1) | 16.2 (22.2) | 3.9 (−3.4, 11.2) | 36 |
| 6.5 | 15.6 (16.9) | 13.4 (19.4) | 2.1 (−4.2, 8.5) | 36 |
| 7 | 14.8 (16.5) | 11.8 (16.9) | 2.9 (−3.4, 9.2) | 36 |
| 8 | 13.8 (16.9) | 10.9 (15.0) | 2.6 (−3.2, 8.4) | 35 |
| 9 | 13.0 (16.8) | 12.7 (16.3) | −2.2 (−8.6, 4.0) | 30 |
| 9.5 | 10.0 (15.1) | 9.9 (14.4) | −1.8 (−7.2, 3.6) | 27 |
| 10 | 4.6 (6.4) | 10.4 (14.6) | −4.2 (−9.8, 1.3) | 22 |
| 11 | 6.6 (10.5) | 10.9 (17.3) | −4.3 (−11.0, 2.4) | 21 |
| Summed pain measures | ||||
| SUMPI3.5−6 | 66.0 (59.6) | 63.3 (77.1) | 2.7 (−21.2, 26.7) | 36 |
| SUMPI6.5−9 | 47.9 (54.6) | 40.7 (53.2) | 7.2 (−12.1, 26.5) | 36 |
| SUMPI9.5−11 | 11.1 (14.1) | 26.0 (38.6) | −14.9 (−29.0, −0.9)* | 27 |
| SUMPI3.5−11 | 124.4 (117.8) | 121.1 (157.4) | 3.3 (−47.7, 54.3) | 36 |
*
Significant difference (P < 0.05, two-tailed Wilcoxon signed ranks test).