Table 3.
Pain intensity first to fourth postoperative day, global efficacy, drug preference score and mean difference between treatments after paracetamol 1000 mg × 4 or ibuprofen 600 mg × 4 for 3 days. Pain scored on 100 mm VAS. Data presented as mean (SD) and mean differences (95% CI).
| Mean pain intensity | ||||
|---|---|---|---|---|
| Time after surgery | Paracetamol | Ibuprofen | Mean difference | n |
| First postoperative day | ||||
| 08.00 h | 16.7 (18.3) | 10.8 (15.4) | 6.7 (1.1, 12.3)* | 35 |
| 12.00 h | 10.6 (16.1) | 7.9 (12.4) | 2.8 (−2.1, 7.6) | 36 |
| 16.00 h | 11.1 (16.5) | 9.8 (18.9) | 1.3 (−4.3, 6.8) | 36 |
| 20.00 h | 9.6 (15.3) | 9.4 (17.1) | 0.3 (−3.8, 4.3) | 36 |
| Second postoperative day | ||||
| 08.00 h | 17.1 (22.5) | 12.8 (21.1) | 4.1 (−4.5, 12.6) | 35 |
| 12.00 h | 8.8 (14.6) | 8.6 (15.0) | 0.3 (−4.4, 4.9) | 36 |
| 16.00 h | 7.9 (14.3) | 7.6 (15.6) | 0.3 (−4.3, 4.9) | 36 |
| 20.00 h | 7.9 (16.0) | 7.9 (16.3) | 0.1 (−5.0, 5.1) | 36 |
| Third postoperative day | ||||
| Bedtime | 7.6 (15.4) | 15.7 (23.2) | −8.0 (−16.1, 0.0) | 36 |
| Fourth postoperative day | ||||
| Bedtime | 7.7 (14.3) | 12.4 (20.0) | −4.7 (−10.0, 0.5) | 36 |
| Global efficacy of drug regimen | 79.1 (25.6) | 79.7 (24.8) | −0.5 (−9.9, 8.9) | 36 |
| Drug regimen preference | 15.7 (18.0) | 8.6 (14.4) | 7.1 (−2.6, 16.7) | 36 |
*
Significant difference (P < 0.05, two-tailed Wilcoxon signed ranks test).