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Mean ribavirin concentration–time profiles in the initial single-dose (a) and final multiple-dose (b) studies and steady-state phase (c) in patients treated with interferon-alpha 2b plus ribavirin combination therapy. —, Patients with sustained virological response; —, those with virological response during treatment, but without sustained virological response after cessation of treatment; ·····, patients without virological response throughout the study period.
