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Interferon-alpha (IFN-α) 2b concentration–time profiles in the initial single-dose (a) and final multiple-dose (b) studies in patients treated with IFN-α 2b plus ribavirin combination therapy. —, Patients with sustained virological response; —, those with virological response during treatment, but without sustained virological response after cessation of treatment; ·····, patients without virological response throughout the study period.
