Table 1.
Study 1* | Study 2† | |
---|---|---|
Patient group | Stable CHF | Stable and unstable CHF |
Study design | Randomized, double blind, parallel group | Randomized, double blind, parallel group |
Study size | 151‡ | 146§ |
Nominal sampling times¶ | 0, 0.5, 1, 2, 4, 8, 24, 24.5, 25, 26 | 0, 1, 2, 3, 4, 6, 24, 24.5, 25, 26, 28, 30, 48, 50/52**, 54 |
Bolus dose (µg kg−1) | 3, 6, 12, 24, 36 | 6 |
Infusion rates (µg.kg min−1) | 0.05, 0.1, 0.2, 0.4, 0.6 | 0.1, 0.2, 0.3, 0.4 |
Infusion durations (h) | 24 | 6-48 |