Table 1.
Pharmacokinetic parameters for piperacillin and for tazobactam, after intravenous administration to patients with pneumonia.
| Ratio | AUC | ||||
|---|---|---|---|---|---|
| AUCinterstitium/ AUCserum | (mg.h l−1) | t½(h) | tmax(h) | Cmax(mg l−1) | |
| Serum | |||||
| Piperacillin | 470 ± 142 | 0.943 ± 0.52 | – | 326 ± 60.6 | |
| Tazobactam | 36.2 ± 26.0 | 0.656 ± 0.456 | – | 30.7 ± 5.88 | |
| Lung | |||||
| Piperacillin | 0.63 ± 0.29 | 288 ± 167 | 1.47 ± 1.28 | 0.627 ± 0.501 | 176 ± 105 |
| Tazobactam | 1.93 ± 1.56 | 45.7 ± 44.8 | 1.2 ± 1.53 | 0.575 ± 0.121 | 20.5 ± 14.5 |
| Muscle | |||||
| Piperacillin | 0.40 ± 0.13 | 197 ± 122.0 | 1.30 ± 0.615 | 0.62 ± 0.323 | 76.1 ± 22.4 |
| Tazobactam | 0.73 ± 0.64 | 19.6 ± 21.8 | 0.713 ± 0.557 | 0.463 ± 0.343 | 11.4 ± 8.12 |
AUC, Area under the concentration–time curve; t1/2, elimination half-life; tmax, time to maximum concentration; Cmax, maximum concentration; mean values ± standard deviation (n = 5).