Table 6.
Genotype percentages and allele frequencies of MDR-1 (C3435T) polymorphism in various ethnic groups.
| Genotype % | Allele frequency | P | ||||||
|---|---|---|---|---|---|---|---|---|
| Population | n | C/C | C/T | T/T | C | T | (vs. Egyptians) | Reference |
| Egyptians | 200 | 34.00 | 51.50 | 14.50 | 0.600 | 0.400 | Present study | |
| Caucasians | ||||||||
| British | 190 | 24.00 | 48.00 | 28.00 | 0.480 | 0.520 | 0.0005 | [42] |
| Portuguese | 100 | 22.00 | 42.00 | 36.00 | 0.430 | 0.570 | <0.0001 | [42] |
| German | 188 | 28.00 | 48.00 | 24.00 | 0.520 | 0.480 | <0.0001 | [16] |
| Saudi | 96 | 37.00 | 38.00 | 26.00 | 0.550 | 0.450 | NS | [42] |
| Asians | ||||||||
| Japanese | 50 | 34.00 | 46.00 | 20.00 | 0.570 | 0.430 | NS | [43] |
| Chinese | 132 | 32.00 | 42.00 | 26.00 | 0.530 | 0.470 | NS | [42] |
| Filipino | 60 | 38.00 | 42.00 | 20.00 | 0.590 | 0.410 | NS | [42] |
| South-west Asian | 89 | 15.00 | 38.00 | 47.00 | 0.340 | 0.660 | <0.0001 | [42] |
| Africans | ||||||||
| Sudanese | 51 | 52.00 | 43.00 | 6.00 | 0.730 | 0.270 | <0.0001 | [42] |
| Kenyan | 80 | 70.00 | 26.00 | 4.00 | 0.830 | 0.170 | <0.0001 | [42] |
| Ghanaian | 206 | 66.00 | 34.00 | 0 | 0.830 | 0.170 | <0.0001 | [42] |
| African-Americans | 88 | 68.00 | 31.00 | 1.00 | 0.840 | 0.160 | <0.0001 | [42] |
n, Number of subjects. Differences in allele frequencies were measured using Fisher's exact test. NS, There were no significant differences (P > 0.05).