. 2003 Aug;56(2):205–213. doi: 10.1046/j.1365-2125.2003.01871.x

Table 2. Final estimates of population pharmacokinetics parameters.

	Population mean	Inter-individual variation (CV%)
CL (l h⁻¹)	4.47 + 0.0738 × CLcr^*	25.5 (20.7–29.6)
	(3.27–5.67) (0.0581–0.0896)
Vc (l)	12.0 + 0.163 × BW^†	21.4 (17.0–24.10)
	(7.5–16.5) (0.081–0.246)
K₁₂ (h⁻¹)	0.304 (0.069–0.540)	–^‡
k₂₁ (h⁻¹)	0.925 (0.470–1.381)	39.7 (20.3–52.5)
Intra-individual variation (CV%)		12.6 (10.5–14.4)

CLcr (ml min⁻¹): calculated CLcr by Cockcroft–Gault formula.

^†

BW (kg), Body weight.

^‡

Not estimated. Values in parentheses are 95% confidence intervals calculated using the standard error estimates by NONMEM.