Table 3. Comparison of 95% confidence intervals estimated by SE of the NONMEM final estimates, objective function mapping and bootstrapping and Jackknife estimate.
| NONMEM final estimate | Objective function mapping | |||||
|---|---|---|---|---|---|---|
| Parameters 95% CI | Mean | SE | 95% CI | 95% CI | ||
| Intercept for CL | 4.47 | 0.61 | (3.27–5.67) | (3.24–5.71) | ||
| Slope for CL | 0.0738 | 0.0080 | (0.0581–0.0895) | (0.0578–0.0904) | ||
| Intercept for Vc | 12.0 | 2.3 | (7.5–16.5) | (7.7–16.5) | ||
| Slope for Vc | 0.163 | 0.042 | (0.081–0.245) | (0.082–0.246) | ||
| k12 | 0.304 | 0.120 | (0.069–0.539) | (0.195–0.476) | ||
| k21 | 0.925 | 0.232 | (0.470–1.380) | (0.628–1.230) | ||
| ω2 for CL | 0.0649 | 0.0112 | (0.0429–0.0869) | (0.052–0.079) | ||
| ω2 for Vc | 0.0456 | 0.0084 | (0.0291–0.0621) | (0.034–0.061) | ||
| ω2 for k21 | 0.158 | 0.060 | (0.041–0.275) | (0.051–0.280) | ||
| σ2 | 0.0158 | 0.0024 | (0.0110–0.0206) | (0.012–0.022) | ||
| Bootstrap resampling | Jackknife estimation | |||||
| Parameters | Mean | SE | 95% CI | Mean | SE | 95% CI |
| Intercept for CL | 4.57 | 0.64 | (3.31–5.82) | 4.28 | 0.77 | (2.54–6.02) |
| Slope for CL | 0.0740 | 0.0084 | (0.0575–0.0905) | 0.0769 | 0.0098 | (0.0546–0.0991) |
| Intercept for Vc | 12.2 | 2.1 | (8.0–16.3) | 11.6 | 2.4 | (6.2–17.1) |
| Slope for Vc | 0.162 | 0.040 | (0.084–0.241) | 0.168 | 0.044 | (0.068–0.267) |
| k12 | 0.287 | 0.041 | (0.206–0.368) | 0.289 | 0.120 | (0.018–0.559) |
| k21 | 0.891 | 0.082 | (0.730–1.052) | 0.934 | 0.225 | (0.425–1.443) |
| ω2 for CL | 0.0629 | 0.0074 | (0.0484–0.0774) | 0.0657 | 0.0117 | (0.0394–0.0921) |
| ω2 for Vc | 0.0444 | 0.0071 | (0.0305–0.0583) | 0.0461 | 0.0067 | (0.0311–0.0612) |
| ω2 for k21 | 0.146 | 0.050 | (0.049–0.243) | 0.145 | 0.070 | (− 0.013 to 0.304) |
| σ2 | 0.0152 | 0.0012 | (0.0129–0.0175) | 0.0164 | 0.0022 | (0.0114–0.0215) |
95% CI, 95% Confidence intervals.