Table 2.
Summary of mean pharmacokinetic parameters for voriconazole in plasma before (day 7) and after (day 14) coadministration with erythromycin, azithromycin, or placebo.
| Voriconazole + erythromycin | Voriconazole + azithromycin | Voriconazole + placebo | ||||
|---|---|---|---|---|---|---|
| Parameter | Day 7 | Day 14 | Day 7 | Day 14 | Day 7 | Day 14 |
| Cmax (ng ml−1)* | 1779 (57) | 1676 (44) | 1819 (85) | 1870 (70) | 1866 (62) | 1633 (56) |
| AUCτ (ng·h ml−1)* | 9511 (96) | 8655 (85) | 10 734 (114) | 10 416 (115) | 10 506 (90) | 9449 (88) |
| tmax (h)† | 2.0 ± 0.6 | 1.6 ± 0.2 | 1.9 ± 0.7 | 1.7 ± 0.6 | 1.9 ± 0.5 | 1.8 ± 0.6 |
*
Geometric mean with coefficient of variation (%) in parentheses.
†
Arithmetic mean ± s.d.