Table 3.
Comparison of mean pharmacokinetic parameters for voriconazole in plasma at day 14 and at day 7, within each group and compared with placebo
| Parameter | Voriconazole + erythromycin | Voriconazole + azithromycin | Voriconazole + placebo |
|---|---|---|---|
| Mean day 14/day 7 ratio (90% CI) | |||
| Cmax | |||
| Within study drug administration | 94.2% | 102.8% | 87.5% |
| (83.4, 106.5) | (91.0, 116.2) | (77.4, 98.9) | |
| Corrected for placebo | 107.7% | 117.5% | – |
| (90.6, 128.0) | (98.8, 139.7) | ||
| AUCτ | |||
| Within study drug administration | 91.0% | 97.0% | 89.9% |
| (83.2, 99.5) | (88.7, 106.1) | (82.2, 98.4) | |
| Corrected for placebo | 101.2% | 107.9% | – |
| (89.1, 114.8) | (95.1, 122.4) | ||
| Mean day 14–day 7 difference (90% CI) | |||
| tmax (h) | |||
| Within study drug administration | −0.4 | −0.3 | −0.2 |
| (−0.8, 0.0) | (−0.7, 0.2) | (−0.6, 0.3) | |
| Corrected for placebo | −0.2 | −0.1 | – |
| (−0.8, 0.3) | (−0.7, 0.5) | ||