Table 1.

Summary of mean pharmacokinetic parameters for voriconazole in plasma, following coadministration with placebo, cimetidine, or ranitidine.

	Voriconazole + placebo		Voriconazole + cimetidine		Voriconazole + ranitidine
Parameter	Mean	Mean	Difference/ratio between means*(90% CI)	Mean	Difference/ratio between means*(90% CI)
Cmax (ng ml−1)†	1 906	2 254	118%	1 972	104%
			(106, 132)		(93.1, 115)
AUCτ (ng·h ml−1)†	11 131	13 634	123%	11 582	104%
			(113, 133)		(96.5, 112)
tmax (h)‡	1.7	1.5	−0.2	1.6	0.0
			(−0.4, −0.1)		(−0.3, 0.2)
kel (h−1)‡	0.104	0.104	0.001	0.095	−0.009
			(−0.010, 0.011)		(−0.019, 0.001)
t1/2 (h)§	6.7	6.7	–	7.3	0.6

^*Ratio (%) between means shown for C_max and AUCτ, difference between means for t_max, k_el, and t_1/2.

^†Geometric mean.

^‡Arithmetic mean.

^§Harmonic mean.