Table 3.
Summary of mean pharmacokinetic parameters for phenytoin in plasma (Study B).
| Phenytoin + voriconazole (P + V) | Phenytoin + placebo (P + P) | ||||||
|---|---|---|---|---|---|---|---|
| Parameter | Day 7 | Day 17 | Day 17/day 7 (90% CI) | Day 7 | Day 17 | Day 17/day 7 (90% CI) | P + V/P + P (90% CI) |
| Cmax (µg ml−1)* | 10.15 | 17.09 | 168% | 11.91 | 12.04 | 101% | 167% |
| (150, 189) | (92.2, 111) | (144.0, 193) | |||||
| AUCτ (µg·h ml−1)* | 197 | 364 | 185% | 237 | 243 | 102% | 181% |
| (165, 208) | (93.2, 112) | (156, 210) | |||||
| tmax (h)† | 4.0 | 4.7 | 0.7 | 4.4 | 3.1 | − 1.3 | 2.0 |
| (−1.2, 2.5) | (− 2.8, 0.2) | (− 0.4, 4.4) | |||||
*
Geometric mean; day 21/day 7 comparison expressed as a percentage.
†
Arithmetic mean; day 21–day 7 comparison.