Table 2.

Summary of mean pharmacokinetic parameters for voriconazole in plasma.

		Voriconazole 200 mg		Difference/ratio between means*(90% CI)
Parameter	n	Fasted	Fed
Day 1
Cmax (ng ml−1)†	12	956 ± 382	377 ± 388	39.5%
		(534–1830)	(83–1331)	(28.3, 55.1)
AUCτ (ng·h ml−1)†	12	3141 ± 2075	1787 ± 2257	56.9%
		(1807–8178)	(539–7159)	(46.1, 70.1)
tmax (h)‡	12	1.0 ± 0.3	2.3 ± 0.9	1.2
		(0.5–1.5)	(1.5–4.0)	(0.8, 1.6)
Day 7
Cmax (ng·ml−1)†	12	2038 ± 1158	1332 ± 1105	65.4%
		(1101–4489)	(432–3902)	(51.8, 82.4)
AUCτ (ng·h ml−1)†	12	9598 ± 12107	7520 ± 11429	78.3%
		(4170–38545)	(2205–35350)	(70.0, 87.7)
AUCt (ng·h ml−1)†	12	12511 ± 23091	10284 ± 21372	82.2%
		(4838–69160)	(2703–63880)	(74.4, 90.9)
AUC (ng·h ml−1)†	7	19258 ± 27716	13065 ± 23945	83.4%
		(5077–70576)	(2901–64681)	(69.4, 100.2)
tmax (h)‡	12	1.5 ± 0.6	2.6 ± 0.9	1.1
		(1.0–2.5)	(1.5–4.0)	(0.5, 1.7)
kel (h−1)‡	7	0.0947 ± 0.0095	0.1086 ± 0.0245	0.0098
		(0.0850–0.1095)	(0.0771–0.1555)	(− 0.0059, 0.0255)
t1/2 (h)§	7	7.3	6.4	–
		(6.3–8.2)	(4.5–9.0)
Accumulation ratios
Cmax (ng ml−1)†	12	2.1 ± 0.9	3.5 ± 2.1	165.6%
		(1.1–4.0)	(1.7–8.0)	(123.9, 221.4)
AUCτ (ng·h ml−1)†	12	3.1 ± 1.8	4.2 ± 2.1	137.7%
		(1.6–8.2)	(2.5–9.5)	(116.7, 162.6)

^*Ratio (%) between means shown for C_max, AUC, AUC_t, and AUC_τ, difference between means for t_max and k_el.

^†Geometric mean ± s.d. (range).

^‡Arithmetic mean ± s.d. (range).

^§Harmonic mean ± s.d. (range). s.d., standard deviation.