Table 4.

Measured pharmacokinetic parameters for pseudoephedrine in milk, and simulated average milk concentrations and infant doses

Volunteer	C_max^*(µg l^–1)	t_max^*(h)	t_1/2^*(h)	AUC(0,∞)^*(µg l⁻¹ h)	M : P^*^†	C_av(µg l⁻¹)^‡	Absolute infant dose (µg kg⁻¹ day⁻¹)	Relative infant dose (%)^‡
1	679	1.3	3.9	3240	3.1	540	81	3.8
2	593	1.5	4.8	3639	1.5	607	91	3.2
3	496	2.0	4.5	3531	2.8	589	88	2.2
4	614	1.0	4.4	4518	2.5	753	113	4.3
5	750	1.0	7.2	6443	3.4	1074	161	4.8
6	682	3.1	5.8	5673	3.8	945	142	4.3
7	1003	1.4	6.9	7365	4.1	1227	184	6.7
8	767	2.5	4.5	5365	5.6	894	134	5.0
Mean (95% CI)	698 (572, 824)	1.7 (1.1, 2.3)	5.3 (4.3, 6.3)	4972 (3544, 6040)	3.4 (2.4, 4.4)	829 (621, 1038)	124 (93, 155)	4.3 (3.3, 5.4)

Measured or calculated from the 60 mg single dose of pseudoephedrine HCl;

^†

estimated from single paired milk and plasma samples 1 h after dose;

^‡

calculated at steady-state for a 60 mg dose of pseudoephedrine HCl given four times daily.