Table 3.
The pharmacokinetics of phenobarbitone after administration of drug alone or with retigabine.
| Subject group | Cmax (µg ml−1) | tmax (h) | AUC (µg ml−1 h) | CL/F (ml h−1 kg−1) |
|---|---|---|---|---|
| Alone (n = 13) | ||||
| Mean ± SD | 14.6 ± 1.9 | 3.6 ± 2.4 | 298 ± 38 | 4.35 ± 0.37 |
| Geometric mean | 14.4 | 2.7 | 296 | 4.34 |
| With retigabine (n = 13) | ||||
| Mean ± SD | 15.4 ± 5.0 | 5.7 ± 4.6 | 311 ± 59 | 4.23 ± 0.60 |
| Geometric mean | 14.9 | 4.4 | 307 | 4.18 |
| P values for transformed analysis of variance with factor for | ||||
| Treatment | 0.65 | 0.12 | 0.40 | 0.40 |
| Geometric mean ratio | 103 | – | 104 | 97 |
| 90% confidence limits | 92, 116 | – | 96, 111 | 90, 104 |