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Effect of 48 h of exposure to rifampin (20 µm) (
) or testosterone (10 µm) (
) on triazolam α-hydroxylation activity and on the expression of immunoactive CYP3A4 protein in human hepatocytes in cell culture. Bars indicate the mean (± SEM) values relative to cells cultured with vehicle control (0.5% DMSO). Asterisk (*) indicates a significant difference from 1.0 based on Student's t-test (n = 4 separate experiments for triazolam α-hydroxylation, n = 2 for immunoactive protein).
