Table 2.
Pharmacokinetic parameters (mean (± SD)).
| Kruskal–Wallis | Kruskal–Wallis | Difference in mean value between young and elderly | ||||||
|---|---|---|---|---|---|---|---|---|
| Young male | Elderly male | test | Young female | Elderly female | test | Men | Women | |
| Cmax (ng ml−1) | 40 (± 16) | 93 (± 45) | P < 0.01 | 60 (± 19) | 108 (± 30) | P < 0.001 | 54 | 48 |
| [26, 53] | [56, 131] | [49, 70] | [83, 133] | [17, 90] | [27, 69] | |||
| tmax (h) | 0.8 (± 0.3) | 1.1 (± 0.4) | NS | 1.2 (± 0.4) | 0.8 (± 0.7) | NS | 0.25 | −0.34 |
| [0.6, 1.2] | [0.7, 1.4] | [0.9, 1.4] | [0.2, 1.4] | [−0.12, 0.62] | [−0.83, 0.14 | |||
| Total AUC (ng ml−1 h) | 110 (± 68) | 400 (± 326) | P < 0.01 | 249 (± 133) | 398 (± 189) | P < 0.05 | 289 | 150 |
| [54, 167] | [127, 672] | [178, 320] | [241, 557] | [37, 542] | [12, 287] | |||
| Clearance | ||||||||
| (ml min−1) | 820 (± 445) | 276 (± 179) | P < 0.01 | 376 (± 271) | 209 (± 122) | P < 0.05 | −545 | −167 |
| [448, 1193] | [126, 425] | [232, 520] | [107, 311] | [−909, −181] | [−377, 44] | |||
| (ml min−1 kg−1) | 11.0 (± 6.4) | 3.8 (± 2.5) | P < 0.01 | 5.8 (± 4.8) | 3.0 (± 1.9) | P < 0.02 | −7.2 | −2.9 |
| [5.6, 16.3] | [1.6, 5.9] | [3.3, 8.4] | [1.4, 4.5] | [−12.4, −2.0] | [−6.5, 0.8] | |||
| Half-life (h) | 1.5 (± 0.5) | 2.7 (± 1.2) | P < 0.03 | 2.4 (± 0.9) | 2.3 (± 0.7) | NS | 1.2 | −0.2 |
| [1.1, 1.8] | [1.7, 3.6] | [1.9, 3.9] | [1.7, 2.9] | [0.2, 2.1] | [−0.9, 0.6] | |||
95% confidence intervals are shown in square brackets.