Table 1.

The genotype and allele frequencies of CYP2C19 in a Tamilian population compared with other populations

	Frequencies of CYP2C19
CYP2C19 alleles and genotype	Tamilians (n = 112)	North Indians†(n = 121)	Orientals‡(n = 367)	Caucasians§(n = 837)	Africans*(n = 251)
2C19*1	0.598a	0.703	0.610	0.860	0.814
	(0.507, 0.689)	(0.622, 0.784)	(0.561, 0.659)	(0.837, 0.883)	(0.766, 0.862)
2C19*2	0.379a	0.297	0.305	0.140	0.179
	(0.350, 0.407)	(0.216, 0.378)	(0.258, 0.352)	(0.117, 0.163)	(0.132, 0.226)
2C19*3	0.022b	0	0.085	0	0.007
	(−0.005, 0.049)		(0.057, 0.113)		(0.003, 0.017)
2C19*1/*1	0.295c	0.479	0.384	0.745	0.661
	(0.210, 0.379)	(0.390, 0.568)	(0.335, 0.433)	(0.716, 0.774)	(0.603, 0.719)
2C19*1/*2	0.580d	0.446	0.367	0.230	0.298
	(0.488, 0.671)	(0.358, 0.534)	(0.318, 0.416)	(0.201, 0.258)	(0.242, 0.354)
2C19*1/*3	0.027e	0	0.084	0.005	0.007
	(−0.003, 0.057)		(0.057, 0.113)	(0.001, 0.009)	(−0.003, 0.017)
2C19*2/*2	0.080f	0.074	0.087	0.022	0.027
	(0.030, 0.130)	(0.028, 0.120)	(0.059, 0.115)	(−0.012, 0.031)	(0.007, 0.047)
2C19*2/*3	0.018	0	0.065	0	0.004
	(−0.006, 0.042)		(0.040, 0.090)		(−0.003, 0.011)
2C19*3/*3	0	0	0.010	0	0
			(0, 0.02)

Values given in parentheses are 95% confidence intervals; n = number of subjects;

^†Reference 8;

^‡Compiled data of Orientals (Japanese, Chinese and Thais) calculated from references 5–7;

^§Compiled data of Caucasians (European Americans, Turks, Germans) calculated from references 2 and 3;

^*Reference 4.

^aTamilians vs Caucasians P < 0.0001, Africans P < 0.0001;

^bTamilians vs Orientals P < 0.03, Caucasians P < 0.001;

^cTamilians vs North Indians P < 0.005, Orientals P < 0.0001, Caucasians P < 0.0001;

^dTamilians vs North Indians P < 0.05, Orientals P < 0.0001, Caucasians P < 0.0001, Africans P < 0.0001;

^eTamilians vs Orientals P < 0.03, Caucasian P < 0.03.

^fTamilians vs Caucasians P < 0.002, Africans P < 0.05.