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Time course of plasma omapatrilat concentration on days 1 (a) and 10 (b) after multiple doses of the drug. The tmax for omapatrilat was 0.5–2 h. Mean results are presented for each dose group. 10 mg (•); 25 mg (□); 50 mg (▪); 75 mg (▵); and 125 mg (▴).