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Mean ACE activity after administration of omapatrilat and placebo over 24 h for the single-dose study (a) and over 12 days for the multiple-dose study. Placebo (○); 2.5 mg (⋄); 7.5 mg (•); 25 mg (□); 50 mg (▪); 125 mg (▴); 250 mg (▵); and 500 mg (♦). (b). Note that in the multiple-dose study, the initial reading for omapatrilat dose groups is at 2 h on day 1. Placebo (○); 10 mg (•); 25 mg (□); 50 mg (▪); 75 mg (▵); and 125 mg (▴).
