Table 1.
Omapatrilat dose | |||||||
---|---|---|---|---|---|---|---|
Parameters | 2.5 mg | 7.5 mg | 25 mg | 50 mg | 125 mg | 250 mg | 500 mg |
Cmax (ng ml−1) | 1.28 | 9.6 | 51.09 | 89.29 | 286.35 | 491.61 | 1008.92 |
(0.44) | (7.96) | (23.43) | (49.15) | (162.01) | (303.76) | (645.88) | |
tmax (h)* | 2.0 | 2.0 | 1.5 | 1.5 | 2.25 | 1.25 | 1.5 |
(1.0, 2.0) | (1.0, 6.0) | (0.5, 4.0) | (0.5, 4.0) | (0.5, 3.0) | (05, 3.0) | (0.5, 4.0) | |
AUC(0,t) (ng ml−1h) | 0.43 | 12.52 | 69.19 | 149.6 | 406.52 | 741.39 | 1890.76 |
(0.4) | (17.34) | (12.86) | (48.89) | (85.52) | (309.32) | (803) |
Results are presented as mean (SD).
Median (minimum, maximum).