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. 2003 Oct;56(4):395–406. doi: 10.1046/j.1365-2125.2003.01888.x

Table 1.

Pharmacokinetic parameters following single dose administration of omapatrilat.

Omapatrilat dose
Parameters 2.5 mg 7.5 mg 25 mg 50 mg 125 mg 250 mg 500 mg
Cmax (ng ml−1) 1.28 9.6 51.09 89.29 286.35 491.61 1008.92
(0.44) (7.96) (23.43) (49.15) (162.01) (303.76) (645.88)
tmax (h)* 2.0 2.0 1.5 1.5 2.25 1.25 1.5
(1.0, 2.0) (1.0, 6.0) (0.5, 4.0) (0.5, 4.0) (0.5, 3.0) (05, 3.0) (0.5, 4.0)
AUC(0,t) (ng ml−1h) 0.43 12.52 69.19 149.6 406.52 741.39 1890.76
(0.4) (17.34) (12.86) (48.89) (85.52) (309.32) (803)

Results are presented as mean (SD).

*

Median (minimum, maximum).